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Tedjo Sasmono

Senior Research Fellow

Qualification:

  • Ph.D. (University of Queensland)
  • PGDipSci (University of Queensland)
  • B.Sc(Hons) (Universitas Gadjah Mada)

Dr. R. Tedjo Sasmono is a Senior Research Fellow at the Eijkman Institute. He started his scientific career at the Institute back in 1994, soon after graduated from Gadjah Mada University, Indonesia as a research assistant. He was then pursued a postgraduate diploma study in molecular biology in 1997 at the University of Queensland, Australia. In 2000, he continued his education for doctoral study in molecular biology and obtained his Ph.D. degree from the Institute for Molecular Bioscience, University of Queensland in 2003. Afterward, he performed a short postdoctoral fellowship at the same Institute and in 2004 he continued the postdoctoral training in the Department of Biochemistry and Molecular Biology at Monash University, Australia. He was then moving back to Indonesia and setting up Dengue Research Unit at the Eijkman Institute. Dr. Sasmono received several scholarships/awards such as the Australian IPRS and UQ-IRPS scholarships (2000), the University of Queensland Indonesian Alumni Award (2011), Australia Awards Fellowship (2016), ASTMH Travel Award (2016), and World Intellectual Property Organization (WIPO)-Bioventures for Global Health (BVGH) Sabbatical Fellowship (2018). Currently, Dr. Sasmono is the group leader for Dengue Research Unit. Dr. Sasmono other activities including serving as a member of the National Ethics Commision for Health Research and Development, Indonesia and member of the Medical Research Ethics Committee of the National Institute for Health Research and Development (NIHRD), Ministry of Health of the Republic of Indonesia.

Contacts:

Tel.   : +62-21-3917131

Fax.  : +62-21-3147982

Email: sasmono[at]eijkman.go.id.

Scientific Profile

Book Chapters

  • R. Tedjo Sasmono and Elizabeth Williams. (2012) Generation and Characterization of c-fms-EGFP Transgenic Mice. In “Leukocytes: Method and Protocols”, Robert B. Ashman and Christine Wells (Eds). The Humana Press.
  • R. Tedjo Sasmono and David A. Hume. (2004) The Biology of Macrophages. In “The Innate Immune Response to Infection”, S.E. Kaufmann, R. Medzhitov and S. Gordon (Eds). The American Society of Microbiology press.


Publications

  1. Comparative cytokine profiling identifies common and unique serum cytokine responses in acute chikungunya and dengue virus infection.
    BMC Infect Dis. 2021 Jul 2;21(1):639. doi: 10.1186/s12879-021-06339-6.
    PubMed
  2. Spatiotemporal Heterogeneity of Zika Virus Transmission in Indonesia: Serosurveillance Data from a Pediatric Population.
    Am J Trop Med Hyg. 2021 May 3. pii: tpmd210010. doi: 10.4269/ajtmh.21-0010.
    PubMed
  3. [6]-Gingerol Inhibits Chikungunya Virus Infection by Suppressing Viral Replication.
    Biomed Res Int. 2021 Mar 27;2021:6623400. doi: 10.1155/2021/6623400. eCollection 2021.
    PubMed
  4. Outbreak of severe dengue associated with DENV-3 in the city of Manado, North Sulawesi, Indonesia.
    Int J Infect Dis. 2021 Mar 24;106:185-196. doi: 10.1016/j.ijid.2021.03.065.
    PubMed
  5. Assessment of dengue and COVID-19 antibody rapid diagnostic tests cross-reactivity in Indonesia.
    Virol J. 2021 Mar 11;18(1):54. doi: 10.1186/s12985-021-01522-2.
    PubMed
  6. The Influence of Surface Charge on The Antiviral Effect of Curcumin Loaded in Nanocarrier System.
    Pharm Nanotechnol. 2021 Feb 4. pii: PNT-EPUB-113966. doi: 10.2174/2211738509666210204121258.
    PubMed
  7. Serological cross-reaction and co-infection of dengue and COVID-19 in Asia: Experience from Indonesia.
    Int J Infect Dis. 2020 Oct 25. pii: S1201-9712(20)32248-7. doi: 10.1016/j.ijid.2020.10.043.
    PubMed
  8. Covid-19 and dengue: Double punches for dengue-endemic countries in Asia.
    Rev Med Virol. 2020 Sep 18:e2161. doi: 10.1002/rmv.2161.
    PubMed
  9. Dengue Virus Serotype 4 Is Responsible for the Outbreak of Dengue in East Java City of Jember, Indonesia.
    Viruses. 2020 Aug 20;12(9). pii: v12090913. doi: 10.3390/v12090913.
    PubMed
  10. Dengue: A Minireview.
    Viruses. 2020 Jul 30;12(8). pii: v12080829. doi: 10.3390/v12080829.
    PubMed
  11. Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
    PLoS Negl Trop Dis. 2020 Jul 14;14(7):e0008454. doi: 10.1371/journal.pntd.0008454. eCollection 2020 Jul.
    PubMed
  12. Diagnostic accuracy of 5 different brands of dengue virus non-structural protein 1 (NS1) antigen rapid diagnostic tests (RDT) in Indonesia.
    Diagn Microbiol Infect Dis. 2020 Oct;98(2):115116. doi: 10.1016/j.diagmicrobio.2020.115116. Epub 2020 Jun 20.
    PubMed
  13. Assessment of a multiplex PCR and Nanopore-based method for dengue virus sequencing in Indonesia.
    Virol J. 2020 Feb 13;17(1):24. doi: 10.1186/s12985-020-1294-6.
    PubMed
  14. Antiviral Action of Curcumin Encapsulated in Nanoemulsion Against Four Serotypes of Dengue Virus.
    Pharm Nanotechnol. 2019 Dec 10. pii: PNT-EPUB-102904. doi: 10.2174/2211738507666191210163408.
    PubMed
  15. Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells.
    Nat Prod Bioprospect. 2019 Sep 19. pii: 10.1007/s13659-019-00218-z. doi: 10.1007/s13659-019-00218-z.
    PubMed
  16. Clinical features and virological confirmation of perinatal dengue infection in Jambi, Indonesia: a case report.
    Int J Infect Dis. 2019 Jul 26. pii: S1201-9712(19)30304-2. doi: 10.1016/j.ijid.2019.07.019.
    PubMed
  17. Multiple introductions of dengue virus strains contribute to dengue outbreaks in East Kalimantan, Indonesia, in 2015-2016.
    Virol J. 2019 Jul 25;16(1):93. doi: 10.1186/s12985-019-1202-0.
    PubMed
  18. Epidemiology of dengue hemorrhagic fever in Indonesia: analysis of five decades data from the National Disease Surveillance.
    BMC Res Notes. 2019 Jun 20;12(1):350. doi: 10.1186/s13104-019-4379-9.
    PubMed
  19. Using dengue epidemics and local weather in Bali, Indonesia to predict imported dengue in Australia.
    Environ Res. 2019 May 18;175:213-220. doi: 10.1016/j.envres.2019.05.021.
    PubMed
  20. Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades.
    Rev Med Virol. 2019 May 16:e2037. doi: 10.1002/rmv.2037.
    PubMed
  21. Chikungunya virus infection in Indonesia: a systematic review and evolutionary analysis.
    BMC Infect Dis. 2019 Mar 12;19(1):243. doi: 10.1186/s12879-019-3857-y.
    PubMed
  22. Concurrent infections of dengue virus serotypes in Bali, Indonesia.
    BMC Res Notes. 2019 Mar 12;12(1):129. doi: 10.1186/s13104-019-4164-9.
    PubMed
  23. Community acceptance and willingness-to-pay for a hypothetical Zika vaccine: A cross-sectional study in Indonesia.
    Vaccine. 2019 Feb 7. pii: S0264-410X(19)30147-1. doi: 10.1016/j.vaccine.2019.01.062.
    PubMed
  24. Willingness to Participate and Associated Factors in a Zika Vaccine Trial in Indonesia: A Cross-Sectional Study.
    Viruses. 2018 Nov 18;10(11). pii: v10110648. doi: 10.3390/v10110648.
    PubMed
  25. Baseline Characterization of Dengue Epidemiology in Yogyakarta City, Indonesia, before a Randomized Controlled Trial of Wolbachia for Arboviral Disease Control.
    Am J Trop Med Hyg. 2018 Sep 17. doi: 10.4269/ajtmh.18-0315.
    PubMed
  26. Zika Virus Seropositivity in 1-4-Year-Old Children, Indonesia, 2014.
    Emerg Infect Dis. 2018 Sep;24(9). doi: 10.3201/eid2409.180582.
    PubMed
  27. Dengue infection in international travellers visiting Bali, Indonesia.
    J Travel Med. 2018 Aug 1;25(1). pii: 5065180. doi: 10.1093/jtm/tay061.
    PubMed
  28. Dengue virus serotype distribution based on serological evidence in pediatric urban population in Indonesia.
    PLoS Negl Trop Dis. 2018 Jun 28;12(6):e0006616. doi: 10.1371/journal.pntd.0006616.
    PubMed
  29. Genomic analysis of dengue virus serotype 1 (DENV-1) genotypes from Surabaya, Indonesia.
    Virus Genes. 2018 Apr 3. pii: 10.1007/s11262-018-1558-z. doi: 10.1007/s11262-018-1558-z.
    PubMed
  30. Isolation and complete genome analysis of neurotropic dengue virus serotype 3 from the cerebrospinal fluid of an encephalitis patient.
    PLoS Negl Trop Dis. 2018 Jan 12;12(1):e0006198. doi: 10.1371/journal.pntd.0006198.
    PubMed
  31. Molecular characterization of dengue viruses isolated from patients in Central Java, Indonesia.
    J Infect Public Health. 2017 Oct 19. pii: S1876-0341(17)30253-8. doi: 10.1016/j.jiph.2017.09.019.
    PubMed
  32. Chikungunya Detection during Dengue Outbreak in Sumatra, Indonesia: Clinical Manifestations and Virological Profile.
    Am J Trop Med Hyg. 2017 Sep 25. doi: 10.4269/ajtmh.16-0935.
    PubMed
  33. Genomic characterization of Zika virus isolated from Indonesia.
    Virology. 2017 Jul 26;510:248-251. doi: 10.1016/j.virol.2017.07.026.
    PubMed
  34. Dengue seroprevalence and force of primary infection in a representative population of urban dwelling Indonesian children.
    PLoS Negl Trop Dis. 2017 Jun 15;11(6):e0005621. doi: 10.1371/journal.pntd.0005621. eCollection 2017 Jun.
    PubMed
  35. Phylogenetic and evolutionary analyses of dengue viruses isolated in Jakarta, Indonesia.
    Virus Genes. 2017 Jun 9. doi: 10.1007/s11262-017-1474-7.
    PubMed
  36. Clinical and virological characteristics of dengue in Surabaya, Indonesia.
    PLoS One. 2017 Jun 2;12(6):e0178443. doi: 10.1371/journal.pone.0178443. eCollection 2017.
    PubMed
  37. Dengue in Bali: Clinical characteristics and genetic diversity of circulating dengue viruses.
    PLoS Negl Trop Dis. 2017 May 22;11(5):e0005483. doi: 10.1371/journal.pntd.0005483.
    PubMed
  38. Association of Endothelial Glycocalyx and Tight and Adherens Junctions With Severity of Plasma Leakage in Dengue Infection.
    J Infect Dis. 2017 Mar 15;215(6):992-999. doi: 10.1093/infdis/jix041.
    PubMed
  39. Willingness to pay for a dengue vaccine and its associated determinants in Indonesia: A community-based, cross-sectional survey in Aceh
    Acta Trop. 2017 Feb;166:249-256. doi: 10.1016/j.actatropica.2016.11.035. Epub 2016 Nov 28.
    PubMed
  40. Dengue vaccine acceptance and willingness to pay.
    Hum Vaccin Immunother. 2017 Apr 3;13(4):786-790. doi: 10.1080/21645515.2016.1259045. Epub 2016 Dec 1.
    PubMed
  41. Modifiable determinants of attitude towards dengue vaccination among healthy inhabitants of Aceh, Indonesia: Findings from a community-based survey.
    Asian Pac J Trop Med. 2016 Nov;9(11):1115-1122. doi: 10.1016/j.apjtm.2016.07.036. Epub 2016 Oct 22.
    PubMed
  42. Production of recombinant dengue non-structural 1 (NS1) proteins from clinical virus isolates.
    Protein Expr Purif. 2016 Sep 17. pii: S1046-5928(16)30239-X. doi: 10.1016/j.pep.2016.09.007.
    PubMed
  43. Community Willingness to Participate in a Dengue Study in Aceh Province, Indonesia.
    PLoS One. 2016 Jul 12;11(7):e0159139. doi: 10.1371/journal.pone.0159139. eCollection 2016.
    PubMed
  44. Dengue score: a proposed diagnostic predictor for pleural effusion and/or ascites in adults with dengue infection.
    BMC Infect Dis. 2016 Jul 8;16(1):322.
    PubMed
  45. The molecular and clinical features of dengue during outbreak in Jambi, Indonesia in 2015.
    Pathog Glob Health. 2016 May 23:1-11.
    PubMed
  46. Dengue vaccine acceptance and associated factors in Indonesia: A community-based cross-sectional survey in Aceh.
    Vaccine. 2016 May 18. pii: S0264-410X(16)30316-4. doi: 10.1016/j.vaccine.2016.05.026.
    PubMed
  47. Isolation of Zika Virus from Febrile Patient, Indonesia.
    Emerg Infect Dis. 2016 May;22(5):924-925. doi: 10.3201/eid2205.151915.
    PubMed
  48. Concurrent infections of dengue viruses serotype 2 and 3 in patient with severe dengue from Jakarta, Indonesia.
    Asian Pac J Trop Med. 2016 Feb;9(2):134-40. doi: 10.1016/j.apjtm.2016.01.013. Epub 2016 Jan 13.
    PubMed
  49. Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia.
    Infect Genet Evol. 2015 Mar 14. pii: S1567-1348(15)00090-8. doi: 10.1016/j.meegid.2015.03.006.
    PubMed
  50. Performance of Simplexa dengue molecular assay compared to conventional and SYBR green RT-PCR for detection of dengue infection in Indonesia.
    PLoS One. 2014 Aug 7;9(8):e103815. doi: 10.1371/journal.pone.0103815. eCollection 2014.
    PubMed
  51. Molecular surveillance of Dengue in Sukabumi, West Java province, Indonesia.
    J Infect Dev Ctries. 2014 Jun 11;8(6):733-41. doi: 10.3855/jidc.3959.
    PubMed
  52. Growth characteristics and cytokine/chemokine induction profiles of dengue viruses in various cell lines.
    Acta Virol. 2014;58(1):20-7.
    PubMed
  53. Performance of commercial dengue NS1 ELISA and molecular analysis of NS1 gene of dengue viruses obtained during surveillance in Indonesia.
    BMC Infect Dis. 2013 Dec 29;13:611. doi: 10.1186/1471-2334-13-611.
    PubMed
  54. Molecular surveillance of dengue in Semarang, Indonesia revealed the circulation of an old genotype of dengue virus serotype-1.
    PLoS Negl Trop Dis. 2013 Aug 8;7(8):e2354. doi: 10.1371/journal.pntd.0002354. eCollection 2013.
    PubMed
  55. Heterogeneity of Mycobacterium tuberculosis strains in Makassar, Indonesia.
    Int J Tuberc Lung Dis. 2012 Nov;16(11):1441-8. doi: 10.5588/ijtld.12.0055.
    PubMed
  56. Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.
    PLoS One. 2012;7(5):e36703. doi: 10.1371/journal.pone.0036703. Epub 2012 May 8.
    PubMed
  57. Generation and characterization of MacGreen mice, the Cfs1r-EGFP transgenic mice.
    Methods Mol Biol. 2012;844:157-76. doi: 10.1007/978-1-61779-527-5_11.
    PubMed
  58. The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene.
    J Immunol. 2008 May 15;180(10):6733-42.
    PubMed
  59. Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter.
    Dev Biol. 2007 Aug 1;308(1):232-46. Epub 2007 May 25.
    PubMed
  60. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
    J Leukoc Biol. 2007 Jul;82(1):111-23. Epub 2007 Apr 16.
    PubMed
  61. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6.
    Mol Cell Biol. 2007 Mar;27(6):2166-79. Epub 2007 Jan 8.
    PubMed
  62. The JNK are important for development and survival of macrophages.
    J Immunol. 2006 Feb 15;176(4):2219-28.
    PubMed
  63. The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion.
    J Immunol. 2005 Aug 1;175(3):1399-405.
    PubMed
  64. The Biology of Macrophages. In “The Innate Immunity Response to Infection”, S.E. Kaufmann, R. Medzhitov and S. Gordon (Eds).

    PubMed
  65. Nonsyndromic sensorineural deafness associated with the A1555G mutation in the mitochondrial small subunit ribosomal RNA in a Balinese family.
    J Hum Genet. 2003;48(3):119-24.
    PubMed
  66. The mononuclear phagocyte system revisited.
    J Leukoc Biol. 2002 Oct;72(4):621-7.
    PubMed
  67. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse.
    Blood. 2003 Feb 1;101(3):1155-63. Epub 2002 Sep 12.
    PubMed
  68. A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression.
    J Leukoc Biol. 2001 Nov;70(5):812-20.
    PubMed
  69. Developmental genetics of deleted mtDNA in mitochondrial oculomyopathy.
    J Neurol Sci. 1997 Feb 12;145(2):155-62.
    PubMed