Din Syafruddin

Senior Research Fellow

Qualification:

  • M.D. (Hasanuddin University)
  • Ph.D. (Toyama Medical and Pharmaceutical University, Japan)
  • Professor (Hasanuddin University)

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Interests:

  • Molecular biology of the energy transducing membrane of the malaria parasite, to elucidate the cellular function of the two extrachromosomal DNAs in the malarial parasites
  • Molecular mechanisms underlying Plasmodium resistance to antimalarial drugs, particularly mitochondrial inhibitors
  • Molecular taxonomy of the parasite based on the mitochondrial DNA sequence

Awards:

  • Alumni award for scientific publications, Hasanuddin University (2006)
  • Paul Ehrlich Magic-Bullet Award 2008 for the scientific contribution: Germany Antimalarial drug resistance in Indonesia: A molecular analysis (2008)

Publications

  • Within-Host Selection of Drug Resistance in a Mouse Model Reveals Dose-Dependent Selection of Atovaquone Resistance Mutations. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e01867-16. doi: 10.1128/AAC.01867-16. Print 2017 May.
  • A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms. N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.
  • Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines. Adv Biomed Res. 2016 Jun 8;5:104. doi: 10.4103/2277-9175.183664. eCollection 2016.
  • Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes. Science. 2016 Apr 15;352(6283):349-53. doi: 10.1126/science.aad9279.
  • A zoonotic human infection with simian malaria, Plasmodium knowlesi, in Central Kalimantan, Indonesia. Malar J. 2016 Apr 16;15(1):218.
  • Behaviour and molecular identification of Anopheles malaria vectors in Jayapura district, Papua province, Indonesia. Malar J. 2016 Apr 8;15(1):192. doi: 10.1186/s12936-016-1234-5.
  • Performance of four HRP-2/pLDH combination rapid diagnostic tests and field microscopy as screening tests for malaria in pregnancy in Indonesia: a cross-sectional study. Malar J. 2015 Oct 29;14(1):420. doi: 10.1186/s12936-015-0943-5.
  • Within-Host Selection of Drug Resistance in a Mouse Model of Repeated Incomplete Malaria Treatment: Comparison between Atovaquone and Pyrimethamine. Antimicrob Agents Chemother. 2015 Oct 26;60(1):258-63. doi: 10.1128/AAC.00538-15.
  • Distribution of Plasmodium vivax pvdhfr and pvdhps alleles and their association with sulfadoxine-pyrimethamine treatment outcomes in Indonesia. Malar J. 2015 Sep 22;14(1):365. doi: 10.1186/s12936-015-0903-0.
  • Is asymptomatic malaria really asymptomatic? Hematological, vascular and inflammatory effects of asymptomatic malaria parasitemia. J Infect. 2015 Nov;71(5):587-96. doi: 10.1016/j.jinf.2015.08.005. Epub 2015 Aug 21.
  • Molecular characterization of various trichomonad species isolated from humans and related mammals in Indonesia. Korean J Parasitol. 2014 Oct;52(5):471-8. doi: 10.3347/kjp.2014.52.5.471. Epub 2014 Oct 22.
  • Direct evidence for the atovaquone action on the Plasmodium cytochrome bc complex. Parasitol Int. 2014 Sep 28. pii: S1383-5769(14)00133-0. doi: 10.1016/j.parint.2014.09.011.
  • Antibody response against three Plasmodium falciparum merozoite antigens in Mamuju District, West Sulawesi Province, Indonesia. Malar J. 2014 Sep 25;13:381. doi: 10.1186/1475-2875-13-381.
  • Tracing the tiger: population genetics provides valuable insights into the Aedes (Stegomyia) albopictus invasion of the Australasian Region. PLoS Negl Trop Dis. 2013 Aug 8;7(8):e2361. doi: 10.1371/journal.pntd.0002361. eCollection 2013.
  • Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers. PLoS One. 2013 Jun 3;8(6):e64850. doi: 10.1371/journal.pone.0064850. Print 2014.
  • Progress towards malaria elimination in Sabang Municipality, Aceh, Indonesia. Malar J. 2013 Jan 30;12:42. doi: 10.1186/1475-2875-12-42.
  • The effect of primaquine on gametocyte development and clearance in the treatment of uncomplicated falciparum malaria with dihydroartemisinin-piperaquine in South sumatra, Western indonesia: an open-label, randomized, controlled trial. Clin Infect Dis. 2013 Mar;56(5):685-93. doi: 10.1093/cid/cis959. Epub 2012 Nov 21.
  • The baseline distribution of malaria in the initial phase of elimination in Sabang Municipality, Aceh Province, Indonesia. Malar J. 2012 Aug 21;11:291. doi: 10.1186/1475-2875-11-291.
  • Serious and fatal illness associated with falciparum and vivax malaria among patients admitted to hospital at West Sumba in eastern Indonesia. Am J Trop Med Hyg. 2012 Jul;87(1):41-9. doi: 10.4269/ajtmh.2012.11-0577.
  • Existence of the rdl mutant alleles among the anopheles malaria vector in Indonesia. Malar J. 2012 Feb 25;11:57. doi: 10.1186/1475-2875-11-57.
  • Malaria in pregnancy in the Asia-Pacific region. Lancet Infect Dis. 2012 Jan;12(1):75-88. doi: 10.1016/S1473-3099(11)70315-2.
  • Phenotyping clinical resistance to chloroquine in Plasmodium vivax in northeastern Papua, Indonesia. Int J Parasitol Drugs Drug Resist. 2011 Oct 5;1(1):28-32. doi: 10.1016/j.ijpddr.2011.08.001. eCollection 2011 Dec.
  • Detection of 1014F kdr mutation in four major Anopheline malaria vectors in Indonesia. Malar J. 2010 Nov 8;9:315. doi: 10.1186/1475-2875-9-315.
  • Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria. Haematologica. 2010 Jul;95(7):1068-74. doi: 10.3324/haematol.2009.019331. Epub 2010 Feb 4.
  • Seasonal distribution of anti-malarial drug resistance alleles on the island of Sumba, Indonesia. Malar J. 2009 Sep 29;8:222. doi: 10.1186/1475-2875-8-222.
  • Quantitative determination of Plasmodium vivax gametocytes by real-time quantitative nucleic acid sequence-based amplification in clinical samples. Am J Trop Med Hyg. 2009 Aug;81(2):366-9.
  • Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10272-7. doi: 10.1073/pnas.0811273106. Epub 2009 Jun 9.
  • Efficacy of artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba District, East Nusa Tenggara Province, Indonesia, and genotypic profiles of the parasite. Am J Trop Med Hyg. 2009 Jun;80(6):914-8.
  • ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria. Am J Trop Med Hyg. 2009 Mar;80(3):492-8.
  • Seasonal prevalence of malaria in West Sumba district, Indonesia. Malar J. 2009 Jan 9;8:8. doi: 10.1186/1475-2875-8-8.
  • The effects of docosahexaenoic acid-rich fish oil on behavior, school attendance rate and malaria infection in school children--a double-blind, randomized, placebo-controlled trial in Lampung, Indonesia. Asia Pac J Clin Nutr. 2008;17(2):258-63.
  • Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo(2)) of the cytochrome b gene. Parasitol Int. 2008 Jun;57(2):229-32. doi: 10.1016/j.parint.2007.12.002. Epub 2007 Dec 8.
  • TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16645-50. Epub 2007 Oct 9.
  • Malaria prevalence in Nias District, North Sumatra Province, Indonesia. Malar J. 2007 Aug 30;6:116.
  • Malaria in Wanokaka and Loli sub-districts, West Sumba District, East Nusa Tenggara Province, Indonesia. Am J Trop Med Hyg. 2006 May;74(5):733-7.
  • Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship. Biol Pharm Bull. 2006 May;29(5):1050-2.
  • Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum. J Nat Prod. 2005 May;68(5):706-10.
  • Molecular epidemiology of Plasmodium falciparum resistance to antimalarial drugs in Indonesia. Am J Trop Med Hyg. 2005 Feb;72(2):174-81.
  • Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Purworejo district, Central Java Province, Indonesia. Am J Trop Med Hyg. 2003 Dec;69(6):614-20.
  • Plasmodium falciparum. Mechanisms of innate and acquired protection against Plasmodium falciparum in Javanese transmigrant adults and children newly resident in malaria-endemic Northwest Papua. SO - Adv Exp Med Biol. 2003;531:83-102.
  • Molecular basis of antimalarial drug resistance in Indonesia. Adv Exp Med Biol. 2003;531:103-15.
  • Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone. Mol Biochem Parasitol. 1999 Nov 30;104(2):185-94.
  • The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitors. Mol Biochem Parasitol. 1997 Jan;84(1):137-41.
  • In vitro evaluation of fluorescein for testing the permeability of white spots on tooth enamel. Pediatr Dent. 1990 Sep-Oct;12(5):308-11.