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Din Syafruddin

Principal Research Fellow

Qualification:

  • M.D. (Hasanuddin University)
  • Ph.D. (Toyama Medical and Pharmaceutical University, Japan)
  • Professor (Hasanuddin University)

He was trained in medicine and doctoral degree in the parasite cell biology, he is currently a senior research fellow at the Malaria and Vector Resistance Laboratory at the Eijkman Institute for Molecular Biology, Jakarta and Professor and chairman of the Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.  He joined the Eijkman Institute in 1993 as a post doctoral research fellow and was involved in a research project to elucidate the role of the extrachromosomal DNAs in the assembly of the mitochondrial energy transducing membrane of the malarial parasite.  His current research activities include molecular mechanisms underlying Plasmodium resistance to antimalarial drug, antimalarial drug discovery, molecular taxonomy of the mosquito vector and the molecular studies on the vector resistance to insecticides. 

Interests:

  • Molecular biology of the energy transducing membrane of the malaria parasite, to elucidate the cellular function of the two extrachromosomal DNAs in the malarial parasites
  • Molecular mechanisms underlying Plasmodium resistance to antimalarial drugs, particularly mitochondrial inhibitors
  • Molecular taxonomy of the parasite based on the mitochondrial DNA sequence

Publications

  1. Intermittent screening and treatment or intermittent preventive treatment compared to current policy of single screening and treatment for the prevention of malaria in pregnancy in Eastern Indonesia: acceptability among health providers and pregnant women.
    Malar J. 2018 Sep 27;17(1):341. doi: 10.1186/s12936-018-2490-3.
    PubMed
  2. Evaluation of the national policy of single screening and treatment for the prevention of malaria in pregnancy in two districts in Eastern Indonesia: health provider perceptions.
    Malar J. 2018 Aug 24;17(1):309. doi: 10.1186/s12936-018-2426-y.
    PubMed
  3. Evaluation of the implementation of single screening and treatment for the control of malaria in pregnancy in Eastern Indonesia: a systems effectiveness analysis.
    Malar J. 2018 Aug 24;17(1):310. doi: 10.1186/s12936-018-2448-5.
    PubMed
  4. Using barrier screens to characterize mosquito composition, flight activity, and abdominal status in South Lampung, Indonesia.
    Parasit Vectors. 2018 Jul 31;11(1):440. doi: 10.1186/s13071-018-3031-1.
    PubMed
  5. Accurate light microscopic diagnosis of South-East Asian ovalocytosis.
    Int J Lab Hematol. 2018 Jul 13. doi: 10.1111/ijlh.12900.
    PubMed
  6. Molecular phylogeny of Blastocystis isolates from wild rodents captured in Indonesia and Japan.
    Parasitol Res. 2018 Sep;117(9):2841-2846. doi: 10.1007/s00436-018-5973-9. Epub 2018 Jul 2.
    PubMed
  7. Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group.
    Malar J. 2018 Jun 20;17(1):241. doi: 10.1186/s12936-018-2380-8.
    PubMed
  8. Therapeutic Response to Dihydroartemisinin-Piperaquine for P. falciparum and P. vivax Nine Years after Its Introduction in Southern Papua, Indonesia.
    Am J Trop Med Hyg. 2018 Mar;98(3):677-682. doi: 10.4269/ajtmh.17-0662. Epub 2018 Jan 11.
    PubMed
  9. Submicroscopic malaria cases play role in local transmission in Trenggalek district, East Java Province, Indonesia.
    Malar J. 2018 Jan 5;17(1):2. doi: 10.1186/s12936-017-2147-7.
    PubMed
  10. Within-Host Selection of Drug Resistance in a Mouse Model Reveals Dose-Dependent Selection of Atovaquone Resistance Mutations.
    Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e01867-16. doi: 10.1128/AAC.01867-16. Print 2017 May.
    PubMed
  11. A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
    N Engl J Med. 2016 Jun 23;374(25):2453-64. doi: 10.1056/NEJMoa1513137.
    PubMed
  12. Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines.
    Adv Biomed Res. 2016 Jun 8;5:104. doi: 10.4103/2277-9175.183664. eCollection 2016.
    PubMed
  13. Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes.
    Science. 2016 Apr 15;352(6283):349-53. doi: 10.1126/science.aad9279.
    PubMed
  14. A zoonotic human infection with simian malaria, Plasmodium knowlesi, in Central Kalimantan, Indonesia.
    Malar J. 2016 Apr 16;15(1):218.
    PubMed
  15. Behaviour and molecular identification of Anopheles malaria vectors in Jayapura district, Papua province, Indonesia.
    Malar J. 2016 Apr 8;15(1):192. doi: 10.1186/s12936-016-1234-5.
    PubMed
  16. Performance of four HRP-2/pLDH combination rapid diagnostic tests and field microscopy as screening tests for malaria in pregnancy in Indonesia: a cross-sectional study.
    Malar J. 2015 Oct 29;14(1):420. doi: 10.1186/s12936-015-0943-5.
    PubMed
  17. Within-Host Selection of Drug Resistance in a Mouse Model of Repeated Incomplete Malaria Treatment: Comparison between Atovaquone and Pyrimethamine.
    Antimicrob Agents Chemother. 2015 Oct 26;60(1):258-63. doi: 10.1128/AAC.00538-15.
    PubMed
  18. Distribution of Plasmodium vivax pvdhfr and pvdhps alleles and their association with sulfadoxine-pyrimethamine treatment outcomes in Indonesia.
    Malar J. 2015 Sep 22;14(1):365. doi: 10.1186/s12936-015-0903-0.
    PubMed
  19. Is asymptomatic malaria really asymptomatic? Hematological, vascular and inflammatory effects of asymptomatic malaria parasitemia.
    J Infect. 2015 Nov;71(5):587-96. doi: 10.1016/j.jinf.2015.08.005. Epub 2015 Aug 21.
    PubMed
  20. Molecular characterization of various trichomonad species isolated from humans and related mammals in Indonesia.
    Korean J Parasitol. 2014 Oct;52(5):471-8. doi: 10.3347/kjp.2014.52.5.471. Epub 2014 Oct 22.
    PubMed
  21. Direct evidence for the atovaquone action on the Plasmodium cytochrome bc complex.
    Parasitol Int. 2014 Sep 28. pii: S1383-5769(14)00133-0. doi: 10.1016/j.parint.2014.09.011.
    PubMed
  22. Antibody response against three Plasmodium falciparum merozoite antigens in Mamuju District, West Sulawesi Province, Indonesia.
    Malar J. 2014 Sep 25;13:381. doi: 10.1186/1475-2875-13-381.
    PubMed
  23. Tracing the tiger: population genetics provides valuable insights into the Aedes (Stegomyia) albopictus invasion of the Australasian Region.
    PLoS Negl Trop Dis. 2013 Aug 8;7(8):e2361. doi: 10.1371/journal.pntd.0002361. eCollection 2013.
    PubMed
  24. Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers.
    PLoS One. 2013 Jun 3;8(6):e64850. doi: 10.1371/journal.pone.0064850. Print 2014.
    PubMed
  25. Progress towards malaria elimination in Sabang Municipality, Aceh, Indonesia.
    Malar J. 2013 Jan 30;12:42. doi: 10.1186/1475-2875-12-42.
    PubMed
  26. The effect of primaquine on gametocyte development and clearance in the treatment of uncomplicated falciparum malaria with dihydroartemisinin-piperaquine in South sumatra, Western indonesia: an open-label, randomized, controlled trial.
    Clin Infect Dis. 2013 Mar;56(5):685-93. doi: 10.1093/cid/cis959. Epub 2012 Nov 21.
    PubMed
  27. The baseline distribution of malaria in the initial phase of elimination in Sabang Municipality, Aceh Province, Indonesia.
    Malar J. 2012 Aug 21;11:291. doi: 10.1186/1475-2875-11-291.
    PubMed
  28. Serious and fatal illness associated with falciparum and vivax malaria among patients admitted to hospital at West Sumba in eastern Indonesia.
    Am J Trop Med Hyg. 2012 Jul;87(1):41-9. doi: 10.4269/ajtmh.2012.11-0577.
    PubMed
  29. Existence of the rdl mutant alleles among the anopheles malaria vector in Indonesia.
    Malar J. 2012 Feb 25;11:57. doi: 10.1186/1475-2875-11-57.
    PubMed
  30. Malaria in pregnancy in the Asia-Pacific region.
    Lancet Infect Dis. 2012 Jan;12(1):75-88. doi: 10.1016/S1473-3099(11)70315-2.
    PubMed
  31. Phenotyping clinical resistance to chloroquine in Plasmodium vivax in northeastern Papua, Indonesia.
    Int J Parasitol Drugs Drug Resist. 2011 Oct 5;1(1):28-32. doi: 10.1016/j.ijpddr.2011.08.001. eCollection 2011 Dec.
    PubMed
  32. Detection of 1014F kdr mutation in four major Anopheline malaria vectors in Indonesia.
    Malar J. 2010 Nov 8;9:315. doi: 10.1186/1475-2875-9-315.
    PubMed
  33. Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria.
    Haematologica. 2010 Jul;95(7):1068-74. doi: 10.3324/haematol.2009.019331. Epub 2010 Feb 4.
    PubMed
  34. Seasonal distribution of anti-malarial drug resistance alleles on the island of Sumba, Indonesia.
    Malar J. 2009 Sep 29;8:222. doi: 10.1186/1475-2875-8-222.
    PubMed
  35. Quantitative determination of Plasmodium vivax gametocytes by real-time quantitative nucleic acid sequence-based amplification in clinical samples.
    Am J Trop Med Hyg. 2009 Aug;81(2):366-9.
    PubMed
  36. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.
    Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10272-7. doi: 10.1073/pnas.0811273106. Epub 2009 Jun 9.
    PubMed
  37. Efficacy of artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba District, East Nusa Tenggara Province, Indonesia, and genotypic profiles of the parasite.
    Am J Trop Med Hyg. 2009 Jun;80(6):914-8.
    PubMed
  38. ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria.
    Am J Trop Med Hyg. 2009 Mar;80(3):492-8.
    PubMed
  39. Seasonal prevalence of malaria in West Sumba district, Indonesia.
    Malar J. 2009 Jan 9;8:8. doi: 10.1186/1475-2875-8-8.
    PubMed
  40. The effects of docosahexaenoic acid-rich fish oil on behavior, school attendance rate and malaria infection in school children--a double-blind, randomized, placebo-controlled trial in Lampung, Indonesia.
    Asia Pac J Clin Nutr. 2008;17(2):258-63.
    PubMed
  41. Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo(2)) of the cytochrome b gene.
    Parasitol Int. 2008 Jun;57(2):229-32. doi: 10.1016/j.parint.2007.12.002. Epub 2007 Dec 8.
    PubMed
  42. TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans.
    Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16645-50. Epub 2007 Oct 9.
    PubMed
  43. Malaria prevalence in Nias District, North Sumatra Province, Indonesia.
    Malar J. 2007 Aug 30;6:116.
    PubMed
  44. Malaria in Wanokaka and Loli sub-districts, West Sumba District, East Nusa Tenggara Province, Indonesia.
    Am J Trop Med Hyg. 2006 May;74(5):733-7.
    PubMed
  45. Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship.
    Biol Pharm Bull. 2006 May;29(5):1050-2.
    PubMed
  46. Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum.
    J Nat Prod. 2005 May;68(5):706-10.
    PubMed
  47. Molecular epidemiology of Plasmodium falciparum resistance to antimalarial drugs in Indonesia.
    Am J Trop Med Hyg. 2005 Feb;72(2):174-81.
    PubMed
  48. Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Purworejo district, Central Java Province, Indonesia.
    Am J Trop Med Hyg. 2003 Dec;69(6):614-20.
    PubMed
  49. Plasmodium falciparum. Mechanisms of innate and acquired protection against Plasmodium falciparum in Javanese transmigrant adults and children newly resident in malaria-endemic Northwest Papua.
    SO - Adv Exp Med Biol. 2003;531:83-102.
    PubMed
  50. Molecular basis of antimalarial drug resistance in Indonesia.
    Adv Exp Med Biol. 2003;531:103-15.
    PubMed
  51. Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone.
    Mol Biochem Parasitol. 1999 Nov 30;104(2):185-94.
    PubMed
  52. The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitors.
    Mol Biochem Parasitol. 1997 Jan;84(1):137-41.
    PubMed
  53. In vitro evaluation of fluorescein for testing the permeability of white spots on tooth enamel.
    Pediatr Dent. 1990 Sep-Oct;12(5):308-11.
    PubMed