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The past decades have witnessed the significant increase in dengue research, covering topics on dengue virology, pathogenesis, and immunology and  progress in development of antivirals, vaccines, and new vector-control strategies which are important for dengue control and prevention. Despite the fact, currently there are no antiviral therapies available, and the only licensed vaccine has limited use in the target population below nine years old.

Indonesia has plenty of natural resources and many have potential as antivirus. We sought to screen compounds having properties beneficial for combating dengue, such as anti-inflammatory and inhibition of virus growth. The results generated from this activity may be beneficial in the future development of dengue antiviral therapy.

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Publication

  1. Antiviral Action of Curcumin Encapsulated in Nanoemulsion Against Four Serotypes of Dengue Virus.
    Pharm Nanotechnol. 2019 Dec 10. pii: PNT-EPUB-102904. doi: 10.2174/2211738507666191210163408.
    PubMed
  2. Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells.
    Nat Prod Bioprospect. 2019 Sep 19. pii: 10.1007/s13659-019-00218-z. doi: 10.1007/s13659-019-00218-z.
    PubMed